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New Troponin-I Reference Range

After review of thousands of troponin-I patient profiles and discussions with members of the Cardiology Department, the Laboratory revised the upper limit of normal troponin-I. Previous reference range of 0.00 to 0.04 ng/ml is changed to 0.00 to 0.14 ng/ml. No change is made in the 0.5 ng/ml cutoff indicative of myocardial infarction. The changed normal range will reduce the percentage of indeterminate troponin-I values from 28 percent to 7 percent. Our previous assay (first generation test) had an indeterminate rate of 4 percent to 5 percent. It is likely that the lower the troponin-I result, the better as far as long-term cardiac risk (LDL cholesterol, CRP or BNP). Very low level troponin-I values are not associated with an increased risk of myocardial infarction in the acute care setting unless the troponin-I levels are increasing significantly ( >0.10 ng/ml differences in sequential results).  


Normal  Indeterminate  Positive
Old Troponin-I Range  0.00-0.04  0.05-0.49   >0.50
New Troponin-I Range  0.00-0.14  0.15-0.49   >0.50
Network Reference Lab 11133 Dunn Road
St. Louis, Missouri 63136 USA
phone -- 314.653.4455
toll-free -- 800.533.7720
facsimile -- 314.653.4156